Regulatory T cells protect against diabetic cardiomyopathy in db/db mice.

ABSTRACT:

Aims/introduction

Regulatory T cells (Tregs) have protected against many cardiovascular diseases. This study was intended to explore the effect of Tregs on diabetic cardiomyopathy (DCM) using a db/db mouse model.

Materials and methods

Eight-week-old male db/db mice were randomly divided into four groups: the control group, administered 200 μL phosphate-buffered saline; the small-dose Treg group, administered 10⁵ Tregs; the large-dose Treg group, administered 10⁶ Tregs; and the PC group, administered 100 μg anti-CD25 specific antibody (PC61) and 10⁶ Tregs. After 12 weeks, mice were euthanized. Transthoracic echocardiography was carried out at the beginning and end of the experiment. Relevant basic experiments to evaluate the effects of Tregs o

SUBMITTER: Zhang K 

PROVIDER: S-EPMC11363098 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature