Nonadditivity in Many-Body Interactions between Membrane-Deforming Spheres Increases Disorder.

ABSTRACT: Membrane-induced interactions play an important role in organizing membrane proteins. Measurements of the interactions between two and three membrane deforming objects have revealed their nonadditive nature. They are thought to lead to complex many-body effects, however, experimental evidence is lacking. We here present an experimental method to measure many-body effects in membrane-mediated interactions using colloidal spheres placed between a deflated giant unilamellar vesicles and a planar substrate. The confined colloidal particles cause a large deformation of the membrane while not being physicochemically attached to it and interact through it. Two particles attract with a maximum force of 0.2 pN. For three particles, compact equilateral triangles were preferred over linear arrangemen

SUBMITTER: Azadbakht A 

PROVIDER: S-EPMC11363220 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature