Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging.

ABSTRACT: Emerging evidence suggests that altered myelination is an important pathophysiologic correlate of several neurodegenerative diseases, including Alzheimer and Parkinson's diseases. Thus, improving myelin integrity may be an effective intervention to prevent and treat age-associated neurodegenerative pathologies. It has been suggested that cardiorespiratory fitness (CRF) may preserve and enhance cerebral myelination throughout the adult lifespan, but this hypothesis has not been fully tested. Among cognitively normal participants from two well-characterized studies spanning a wide age range, we assessed CRF operationalized as the maximum rate of oxygen consumption (VO₂max) and myelin content defined by myelin water fraction (MWF) estimated through our advanced multicomponent relax

SUBMITTER: Faulkner ME 

PROVIDER: S-EPMC11363304 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature