Spatiotemporal Communication in Artificial Cell Consortia for Dynamic Control of DNA Nanostructures.

ABSTRACT: The spatiotemporal orchestration of cellular processes is a ubiquitous phenomenon in pluricellular organisms and bacterial communities, where sender cells secrete chemical signals that activate specific pathways in distant receivers. Despite its importance, the engineering and investigation of spatiotemporal communication in artificial cell consortia remains underexplored. In this study, we present spatiotemporal communication between cellular-scale entities acting as both senders and receivers. The transmitted signals are leveraged to elicit conformational alterations within compartmentalized DNA structures. Specifically, sender entities control and generate diffusive chemical signals, namely, variations in pH, through the conversion of biomolecular inputs. In the receiver population, com

SUBMITTER: Llopis-Lorente A 

PROVIDER: S-EPMC11363350 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature