Titanium nanoparticles released from orthopedic implants induce muscle fibrosis via activation of SNAI2.

ABSTRACT: Titanium alloys represent the prevailing material employed in orthopedic implants, which are present in millions of patients worldwide. The prolonged presence of these implants in the human body has raised concerns about possible health effects. This study presents a comprehensive analysis of titanium implants and surrounding tissue samples obtained from patients who underwent revision surgery for therapeutic reasons. The surface of the implants exhibited nano-scale corrosion defects, and nanoparticles were deposited in adjacent samples. In addition, muscle in close proximity to the implant showed clear evidence of fibrotic proliferation, with titanium content in the muscle tissue increasing the closer it was to the implant. Transcriptomics analysis revealed SNAI2 upregulation and activati

SUBMITTER: Zhang G 

PROVIDER: S-EPMC11363368 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature