Trends in central nervous system-active polypharmacy among people with multiple sclerosis.

ABSTRACT:

Background

People with multiple sclerosis (pwMS) are at risk of concurrently using multiple central nervous system (CNS)-active drugs, yet the prevalence of CNS-active polypharmacy remains unmeasured in pwMS.

Objective

The objective is to measure the prevalence of CNS-active polypharmacy in pwMS.

Methods

This serial, cross-sectional study measured CNS-active polypharmacy in people with MS in the United States from 2008 to 2021 using insurance claims data. CNS-active polypharmacy was defined as the concurrent prescription of ⩾3 CNS-active drugs for >30 continuous days. CNS-active drugs included antidepressants, antiepileptics, antipsychotics, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonist hypnotics, opioids, and skeletal muscle relaxants.

Results

SUBMITTER: Naizer H 

PROVIDER: S-EPMC11363472 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature