The level of partial pressure of carbon dioxide affects organ perfusion in respiratory failure patients undergoing pressure support ventilation with venovenous extracorporeal membrane oxygenation: a prospective study.

ABSTRACT:

Background

We evaluated the influence of different partial carbon dioxide pressure (PaCO₂) levels on organ perfusion in patients with respiratory failure receiving pressure-support ventilation with veno-venous extracorporeal membrane oxygenation (V-V ECMO).

Methods

In this twelve patients prospective study, ECMO gas-flow was decreased from baseline (PaCO₂ < 40 mmHg) until PaCO₂ increased by 5-10 mmHg (High-CO₂ phase). Resistance indices of gut, spleen, and snuffbox artery, the peripheral perfusion index (PPI), and heart rate variability were measured at baseline and High-CO₂ phase.

Results

When PaCO₂ increased from 36 (36-37) mmHg at baseline to 42 (41-43) mmHg in the High-CO₂ phase (p < 0.00

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11363615 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature