Association between nonalcoholic fatty liver disease and bone mineral density: Mendelian randomization and mediation analysis.

ABSTRACT:

Background

Observational studies have reported significant association between non-alcoholic fatty liver disease (NAFLD) and bone mineral density (BMD), a critical indicator of bone health. We aimed to investigate whether NAFLD is a cause for changes in BMD.

Methods

We selected 29 independent SNPs as instrumental variables for NAFLD. A range of Mendelian randomization (MR) methods, namely the inverse variance-weighted (IVW) method, weighted-median, weighted-mode, and MR-Egger regression, were utilized to determine the causal effects of NAFLD on BMD. Two-step MR analysis was conducted to determine the mediating effect of fasting glucose, insulin, glycosylated hemoglobin, low-density cholesterol, and body-mass index on the association between NAFLD and BMD. False-discovery-rat

SUBMITTER: Zheng M 

PROVIDER: S-EPMC11363625 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature