Prenatal cell-free DNA testing of women with pregnancy-associated cancer: a retrospective cross-sectional study.

ABSTRACT:

Background

Incidentally, the non-invasive prenatal test (NIPT) shows chromosomal aberrations suspicious of a maternal malignancy, especially after genome-wide testing. The aim of this study is to determine how many cases of cancer in pregnancy are diagnosed or missed with NIPT and whether in retrospect subtle changes in NIPT results could have detected cancer.

Methods

We identified Dutch patients diagnosed in 2017-2021 with pregnancy-associated cancer from the International Network on Cancer, Infertility and Pregnancy (INCIP) Registry, who underwent NIPT in the Dutch NIPT implementation study (TRIDENT-2). We retrospectively assessed how many of these women showed a malignancy suspicious-NIPT, their tumour types and -stages, and the time interval between NIPT and cancer diagn

SUBMITTER: Heesterbeek CJ 

PROVIDER: S-EPMC11363838 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature