Matrisome proteomics reveals novel mediators of muscle remodeling with aerobic exercise training.

ABSTRACT: Skeletal muscle has a unique ability to remodel in response to stimuli such as contraction and aerobic exercise training. Phenotypic changes in muscle that occur with training such as a switch to a more oxidative fiber type, and increased capillary density contribute to the well-known health benefits of aerobic exercise. The muscle matrisome likely plays an important role in muscle remodeling with exercise. However, due to technical limitations in studying muscle ECM proteins, which are highly insoluble, little is known about the muscle matrisome and how it contributes to muscle remodeling. Here, we utilized two-fraction methodology to extract muscle proteins, combined with multiplexed tandem mass tag proteomic technology to identify 161 unique ECM proteins in mouse skeletal muscle. In add

SUBMITTER: Pattamaprapanont P 

PROVIDER: S-EPMC11363848 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature