Serum albumin, genetic susceptibility, and risk of venous thromboembolism.

ABSTRACT:

Background

Previous research on the association between serum albumin (ALB) and venous thromboembolism (VTE) has produced inconclusive results. The polygenic risk score is constructed from a set of independent risk variants associated with a disorder, enabling the identification of a larger fraction of the population at comparable or greater disease risk. It is still unknown whether ALB and genetic factors jointly contribute to the incidence of VTE.

Objectives

The present study aimed to explore ALB, genetic susceptibility, and the risk of VTE.

Methods

The present investigation was an analysis of prospectively collected data from UK Biobank, a population-based, longitudinal cohort. Cox proportional models were used to calculate hazard ratios and 95% CIs for VTE. The Ka

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11364004 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature