A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration.

ABSTRACT: The bone-cartilage interface is defined by a unique arrangement of cells and tissue matrix. Injury to the interface can contribute to the development of arthritic joint disease. Attempts to repair osteochondral damage through clinical trials have generated mixed outcomes. Tissue engineering offers the potential of integrated scaffold design with multiregional architecture to assist in tissue regeneration, such as the bone-cartilage interface. Challenges remain in joining distinct materials in a single scaffold mass while maintaining integrity and avoiding delamination. The aim of the current work is to examine the possibility of joining two closely related acrylamide derivatives such as, poly n-isopropyl acrylamide (pNIPAM) and poly n‑tert‑butyl acrylamide (pNTBAM). The target is to produc

SUBMITTER: Younus ZM 

PROVIDER: S-EPMC11364006 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature