3D-printed aerogels as theranostic implants monitored by fluorescence bioimaging.

ABSTRACT: Aerogel scaffolds are nanostructured materials with beneficial properties for tissue engineering applications. The tracing of the state of the aerogels after their implantation is challenging due to their variable biodegradation rate and the lack of suitable strategies capable of in vivo monitoring the scaffolds. Upconversion nanoparticles (UCNPs) have emerged as advanced tools for in vitro bioimaging because of their fluorescence properties. In this work, highly fluorescent UCNPs were loaded into aerogels to obtain theranostic implants for tissue engineering and bioimaging applications. 3D-printed alginate-hydroxyapatite aerogels labeled with UCNPs were manufactured by 3D-printing and supercritical CO₂ drying to generate personalize-to-patient aerogels. The physic

SUBMITTER: Iglesias-Mejuto A 

PROVIDER: S-EPMC11364008 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature