<i>Lactobacillus acidophilus</i> ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.

ABSTRACT: Gut microbiota dysbiosis is involved in cholestatic liver diseases. However, the mechanisms remain to be elucidated. The purpose of this study was to examine the effects and mechanisms of Lactobacillus acidophilus (L. acidophilus) on cholestatic liver injury in both animals and humans. Bile duct ligation (BDL) was performed to mimic cholestatic liver injury in mice and serum liver function was tested. Gut microbiota were analyzed by 16S rRNA sequencing. Fecal bacteria transplantation (FMT) was used to evaluate the role of gut microbiota in cholestasis. Bile acids (BAs) profiles were analyzed by targeted metabolomics. Effects of L. acidophilus in cholestatic patients were evaluated by a randomized controlled clinical trial (NO: ChiCTR2200063330). BDL induc

SUBMITTER: Wu L 

PROVIDER: S-EPMC11364073 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature