Context-dependent impact of the dietary non-essential amino acid tyrosine on <i>Drosophila</i> physiology and longevity.

ABSTRACT: Dietary protein intake modulates growth, reproduction, and longevity by stimulating amino acid (AA)-sensing pathways. Essential AAs are often considered as limiting nutrients during protein scarcity, and the role of dietary non-essential AAs (NEAAs) is less explored. Although tyrosine has been reported to be crucial for sensing protein restriction in Drosophila larvae, its effect on adult physiology and longevity remains unclear. Here, using a synthetic diet, we perform a systematic investigation of the effect of single NEAA deprivation on nutrient-sensing pathways, reproductive ability, starvation resistance, feeding behavior, and life span in adult female flies. Specifically, dietary tyrosine deprivation decreases internal tyrosine levels and fecundity, influences AA-sensing machi

SUBMITTER: Kosakamoto H 

PROVIDER: S-EPMC11364096 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature