Comparative genomic analysis identifies potential adaptive variation in Mycoplasma ovipneumoniae.

ABSTRACT: Mycoplasma ovipneumoniae is associated with respiratory disease in wild and domestic Caprinae globally, with wide variation in disease outcomes within and between host species. To gain insight into phylogenetic structure and mechanisms of pathogenicity for this bacterial species, we compared M. ovipneumoniae genomes for 99 samples from 6 countries (Australia, Bosnia and Herzegovina, Brazil, China, France and USA) and 4 host species (domestic sheep, domestic goats, bighorn sheep and caribou). Core genome sequences of M. ovipneumoniae assemblies from domestic sheep and goats fell into two well-supported phylogenetic clades that are divergent enough to be considered different bacterial species, consistent with each of these two clades having an evolutionary origin in sepa

SUBMITTER: Andrews KR 

PROVIDER: S-EPMC11364169 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature