Utilization of formic acid by extremely thermoacidophilic archaea species.

ABSTRACT: The exploration of novel hosts with the ability to assimilate formic acid, a C1 substrate that can be produced from renewable electrons and CO₂, is of great relevance for developing novel and sustainable biomanufacturing platforms. Formatotrophs can use formic acid or formate as a carbon and/or reducing power source. Formatotrophy has typically been studied in neutrophilic microorganisms because formic acid toxicity increases in acidic environments below the pKa of 3.75 (25°C). Because of this toxicity challenge, utilization of formic acid as either a carbon or energy source has been largely unexplored in thermoacidophiles, species that possess the ability to produce a variety of metabolites and enzymes of high biotechnological relevance. Here we investigate the capacity of seve

SUBMITTER: Tejedor-Sanz S 

PROVIDER: S-EPMC11364514 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature