Ultraconformable cuff implants for long-term bidirectional interfacing of peripheral nerves at sub-nerve resolutions.

ABSTRACT: Implantable devices interfacing with peripheral nerves exhibit limited longevity and resolution. Poor nerve-electrode interface quality, invasive surgical placement and development of foreign body reaction combine to limit research and clinical application of these devices. Here, we develop cuff implants with a conformable design that achieve high-quality and stable interfacing with nerves in chronic implantation scenarios. When implanted in sensorimotor nerves of the arm in awake rats for 21 days, the devices record nerve action potentials with fascicle-specific resolution and extract from these the conduction velocity and direction of propagation. The cuffs exhibit high biocompatibility, producing lower levels of fibrotic scarring than clinically equivalent PDMS silicone cuffs. In additi

SUBMITTER: Carnicer-Lombarte A 

PROVIDER: S-EPMC11364531 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature