Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial.

ABSTRACT:

Objectives

A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway disease and emphysema.

Methods

A total of 601 participants with COPD from 15 sites underwent same-day morpho-functional chest MRI and paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping and lung parenchyma defects in each lung lobe and determined COPD phenotype. A third reader acted as adjudicator to establish consensus. Inter-modality and inter-reader agreement were assessed using Cohen's kappa (im-κ and ir-κ).

Results

The mean combined MRI score for bronchiectasis/bronchial wall thickening was 4.5/12 (CT

SUBMITTER: Nauck S 

PROVIDER: S-EPMC11364611 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature