A novel sequential treatment approach between denosumab and romosozumab in patients with severe osteoporosis.

ABSTRACT: In severe osteoporosis, the optimal approach for sequential treatment between denosumab and romosozumab is unclear. We utilised a novel overlapping strategy in three patients with very-high fracture risk despite long-term denosumab which led to greater bone density improvements than previously reported with standard approaches. Larger confirmatory prospective studies are needed.

Purpose/introduction

In patients with severe osteoporosis, the optimal approach for sequential treatment between denosumab and romosozumab has not been established. The ideal strategy would maximise gains in bone mineral density (BMD) with romosozumab and effectively mitigate the risk of rebound increased bone turnover when sequencing from denosumab. Limited studies exploring the sequence from denosumab to r

SUBMITTER: Kumar S 

PROVIDER: S-EPMC11364616 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature