Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease.

ABSTRACT: Neuropsychiatric symptoms (including anxiety, depression, apathy, impulse-compulsive behaviors and hallucinations) are among the most common non-motor features of Parkinson's disease. Whether these symptoms should be considered as a direct consequence of the pathophysiologic mechanisms of Parkinson's disease is controversial. Morphometric similarity network analysis and epicenter mapping approach were performed on T1-weighted images of 505 patients with Parkinson's disease and 167 age- and sex-matched healthy participants from Parkinson's Progression Markers Initiative database to reveal the commonalities and specificities of distinct neuropsychiatric symptoms. Abnormal cortical co-alteration pattern in patients with neuropsychiatric symptoms was in somatomotor, vision and frontoparietal r

SUBMITTER: Lu Q 

PROVIDER: S-EPMC11364691 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature