Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance.

ABSTRACT: The obesity epidemic among children has become a major public health issue, and the presence of childhood insulin resistance (IR) has been demonstrated prior to the onset of type 2 diabetes mellitus. However, it is unclear whether the metabolomic signature is associated with weight loss interventions in obese children with IR. Thirty-six obese children with IR were selected from the weight loss camp (Shenzhen Sunshine Xing Yada health Technology Co., LTD). Clinical parameters were collected before and after weight loss intervention. Targeted metabolomics of plasma samples was performed by ultra-performance liquid chromatography coupled to the tandem mass spectrometry, and principal component analysis, variable importance in projection, and orthogonal partial least squares discriminant anal

SUBMITTER: Liu X 

PROVIDER: S-EPMC11364699 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature