Fasting hyperglycaemia and fatty liver drive colorectal cancer: a retrospective analysis in 1145 patients.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents the hepatic manifestation of increased adiposopathy, whose pathogenetic features have been proposed as tumourigenic triggers for colorectal cancer (CRC). We aim to identify specific metabolic signatures involved in CRC development that may be used as non-invasive biomarkers, paving the way for specific and personalized strategies of CRC prevention and early detection.

Methods

We retrospectively assessed CRC onset during a time frame of 8 years in a cohort of 1145 out-patients individuals who had previously been evaluated for Metabolic Syndrome.

Results

28 patients developed CRC. No association between CRC development and visceral and general obesity was detected, while baseline fast

SUBMITTER: Crudele L 

PROVIDER: S-EPMC11364717 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature