Subphenotypes of platelet count trajectories in sepsis from multi-center ICU data.

ABSTRACT: Although thrombocytopenia on admission to the ICU is associated with increased in-hospital mortality in septic patients, the role of longitudinally measured platelet counts, which are dynamically changing, is unclear. We aimed to identify patterns of dynamic platelet count trajectories and evaluate their association with outcomes and thrombocytopenia in septic patients. We tested the longitudinal platelet trajectory patterns of sepsis patients within the first four days of ICU admission in the MIMIC-IV database and their association with 28-day mortality, and independently validated our findings in the eICU-CRD database. Statistical methods used included multivariate regression, propensity score analysis, doubly robust estimation, gradient boosting model, and inverse probability weighting

SUBMITTER: Wang K 

PROVIDER: S-EPMC11364765 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature