Dataset Information

Lifetime employment trajectories and cancer.

ABSTRACT: Working life is associated with lifestyle, screening uptake, and occupational health risks that may explain differences in cancer onset. To better understand the association between working life and cancer risk, we need to account for the entire employment history. We investigated whether lifetime employment trajectories are associated with cancer risk. We used data from 6809 women and 5716 men, average age 70 years, from the Survey of Health, Ageing, and Retirement in Europe. Employment history from age 16 to 65 was collected retrospectively using a life calendar and trajectories were constructed using sequence analysis. Associations between employment trajectories and self-reported cancer were assessed using logistic regression. We identified eight employment trajectories for women and two for men. Among women, the risk of cancer was higher in the trajectories "Mainly full-time to home/family", "Full-time or home/family to part-time", "Mainly full-time", and "Other" compared with the "Mainly home/family" trajectory. Among men, the risk of cancer was lower in the "Mainly self-employment" trajectory compared with "Mainly full-time". We could show how employment trajectories were associated with cancer risk, underlining the potential of sequence analysis for life course epidemiology. More research is needed to understand these associations and determine if causal relationships exist.

SUBMITTER: Cullati S

PROVIDER: S-EPMC11364773 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Lifetime employment trajectories and cancer.

Cullati Stéphane S Sieber Stefan S Gabriel Rainer R Studer Matthias M Chiolero Arnaud A van der Linden Bernadette W A BWA

Scientific reports 20240830 1

Working life is associated with lifestyle, screening uptake, and occupational health risks that may explain differences in cancer onset. To better understand the association between working life and cancer risk, we need to account for the entire employment history. We investigated whether lifetime employment trajectories are associated with cancer risk. We used data from 6809 women and 5716 men, average age 70 years, from the Survey of Health, Ageing, and Retirement in Europe. Employment history ...[more]

PMID: 39215024

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Project description:ObjectivesAn individual's quality of employment over time has been highlighted as a potential determinant of mental health. With mental ill-health greatly contributing to work incapacities and disabilities in Belgium, the present study aims to explore whether mental health, as indicated by registered mental health-related disability, is structured along the lines of employment quality, whereby employment quality is assessed over time as part of individuals' labour market trajectories.MethodsUsing administrative data from the Belgian Crossroads Bank for Social Security over 16 quarters between 2006 and 2009, transitions between waged jobs of varying quality (based on dimensions of income, working time, employment stability and multiple jobholding), self-employment, and unemployment are considered among individuals in the labour force aged 30-40 at baseline (n = 41,065 women and 45,667 men). With Multichannel Sequence Analysis and clustering, we constructed ideal types of employment trajectories. Fitting Cox regressions, we then evaluated individuals' hazard of experiencing a disability from a mental disorder between 2010 and 2016.ResultsOur analysis highlights various gender-specific trajectories. Among both genders, individuals exposed to near-constant unemployment over the initial 4 years showed the highest hazard of subsequent mental health-related disability compared to a group characterised by stable full-time employment, single jobholding, and above-median income. Trajectories involving a higher probability of subsidised and non-standard employment and (potential) spells of unemployment and lower relative income were also strong predictors of cause-specific disabilities. Health selection and confounding might, however, be contributing factors.ConclusionsOur study shows a gradient of mental disorders resulting in a disability along trajectory types. Our findings highlight the predictive power of labour market trajectories and their employment quality for subsequent mental disorder-related disability. Future research should examine the mechanisms, including selection effects in this association.

Project description:Variation in somatic growth plays a critical role in determining an individual's body size and the expression of its life history. Understanding the environmental drivers of growth variation in mobile organisms such as fishes can be challenging because an individual's growth expression integrates processes operating at different spatial and temporal scales. Traditionally, otolith (ear stone) based growth analyses have focussed on temporal environmental variation by assuming an individual spends its whole life at its capture location. This approach ignores the movement potential of individuals and thus the role of spatio-temporal variation in conditions experienced. Here, we develop a modelling framework that incorporates individual movement information reconstructed via the analysis of chemical tracers in otoliths. We assess whether consideration of movement histories is important to estimating growth of a mobile freshwater fish, golden perch (Macquaria ambigua) at three spatial resolutions: basin-scale, reach-scale (movement-exclusive), and reach-scale (movement-inclusive). The predictive capacity of annual growth models slightly improved from the basin to the reach spatial scales (inclusive or exclusive of movement histories). Contrary to expectations, incorporating individual movement information, did not improve our ability to describe growth patterns. Golden perch growth was linked to the magnitude of and variation in spring, summer, and previous-year (antecedent) discharge, and spring temperature. The direction and magnitude of these effects was, however, dependent on life stage. Adults benefitted strongly from any increase in discharge or temperature, whereas juveniles benefitted only from increased summer discharge and grew slower in years characterised by wetter and warmer springs. We suggest that, for highly mobile fish like golden perch and in the absence of fine, 'within reach' scale biological data, coarser 'reach-scale' environmental variation may adequately describe individual growth trajectories.

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Lifetime employment trajectories and cancer.

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Lifetime employment trajectories and cancer.

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