Association between common chronic pulmonary diseases and lung cancer: Mendelian randomization analysis.

ABSTRACT:

Background

Lung cancer is a leading public health concern worldwide. Previous evidence suggests that chronic obstructive pulmonary disease (COPD) and asthma may contribute to its development. However, whether these common chronic pulmonary diseases are causal factors of lung cancer remained unclear.

Methods

Summary statistics from genome-wide association studies (GWAS) were used for Mendelian randomization (MR) analysis. Genetic data for COPD were obtained from the Global Biobank Meta-Analysis Initiative, and asthma data were retrieved from the UK Biobank cohort. Suitable instrumental variables were selected based on quality control measures. GWAS summary data for lung cancer were obtained from a large study involved 85,716 participants. MR analysis was performed using vario

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11364834 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature