"Three birds, one stone" strategy of NIR-responsive CO/H₂S dual-gas Nanogenerator for efficient treatment of osteoporosis.

ABSTRACT: Osteoporosis (OP), the most prevalent bone degenerative disease, has become a significant public health challenge globally. Current therapies primarily target inhibiting osteoclast activity or stimulating osteoblast activation, but their effectiveness remains suboptimal. This paper introduced a "three birds, one stone" therapeutic approach for osteoporosis, employing upconversion nanoparticles (UCNPs) to create a dual-gas storage nanoplatform (UZPA-CP) targeting bone tissues, capable of concurrently generating carbon monoxide (CO) and hydrogen sulfide (H₂S). Through the precise modulation of 808 nm near-infrared (NIR) light, the platform could effectively control the release of CO and H₂S in the OP microenvironment, and realize the effective combination of promoting o

SUBMITTER: Yang G 

PROVIDER: S-EPMC11364908 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature