Silica 3D printed scaffolds as pH stimuli-responsive drug release platform.

ABSTRACT: Silica-based scaffolds are promising in Tissue Engineering by enabling personalized scaffolds, boosting exceptional bioactivity and osteogenic characteristics. Moreover, silica materials are highly tunable, allowing for controlled drug release to enhance tissue regeneration. In this study, we developed a 3D printable silica material with controlled mesoporosity, achieved through the sol-gel reaction of tetraethyl orthosilicate (TEOS) at mild temperatures with the addition of different calcium concentrations. The resultant silica inks exhibited high printability and shape fidelity, while maintaining bioactivity and biocompatibility. Notably, the increased mesopore size enhanced the incorporation and release of large molecules, using cytochrome C as a drug model. Due to the varying surface c

SUBMITTER: Rodriguez-Gonzalez R 

PROVIDER: S-EPMC11364913 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature