Dosimetric comparison of hippocampal-sparing technologies in patients with low-grade glioma.

ABSTRACT:

Background

Radiotherapy (RT) plays an integral role in the management of low-grade gliomas (LGG). Late toxicity from RT can cause progressive neurocognitive dysfunction. Radiation-induced damage to the hippocampus (HCP) plays a considerable role in memory decline. Advancements in photon planning software have resulted in the development of multi-criteria optimization (MCO) and HyperArc technologies which may improve HCP sparing while maintaining planning target volume (PTV) target coverage.

Methods

Three planning methods for hippocampal sparing (HS) were compared, volumetric modulated arc therapy (VMAT) without HS (VMAT_noHS), VMAT with HS (VMAT_HS), MCO with HS (MCO_HS), and HyperArc with HS (HyperArc_HS).

Results

Twenty-five patients were identified. The contralater

SUBMITTER: Williamson A 

PROVIDER: S-EPMC11364934 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature