Is pulsed saturation transfer sufficient for differentiating radiation necrosis from tumor progression in brain metastases?

ABSTRACT:

Background

Stereotactic radiosurgery (SRS) for the treatment of brain metastases delivers a high dose of radiation with excellent local control but comes with the risk of radiation necrosis (RN), which can be difficult to distinguish from tumor progression (TP). Magnetization transfer (MT) and chemical exchange saturation transfer (CEST) are promising techniques for distinguishing RN from TP in brain metastases. Previous studies used a 2D continuous-wave (ie, block radiofrequency [RF] saturation) MT/CEST approach. The purpose of this study is to investigate a 3D pulsed saturation MT/CEST approach with perfusion MRI for distinguishing RN from TP in brain metastases.

Methods

The study included 73 patients scanned with MT/CEST MRI previously treated with SRS or fractionated SRS

SUBMITTER: Chan RW 

PROVIDER: S-EPMC11364936 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature