Proteomics Exploration of Brucella melitensis to Design an Innovative Multi-Epitope mRNA Vaccine.

ABSTRACT: Brucellosis is a chronic and debilitating disease in humans, causing great economic losses in the livestock industry. Making an effective vaccine is one of the most important concerns for this disease. The new mRNA vaccine technology due to its accuracy and high efficiency has given promising results in various diseases. The objective of this research was to create a novel mRNA vaccine with multiple epitopes targeting Brucella melitensis. Seventeen antigenic proteins and their appropriate epitopes were selected with immunoinformatic tools and surveyed in terms of toxicity, allergenicity, and homology. Then, their presentation and identification by MHC cells and other immune cells were checked with valid tools such as molecular docking, and a multi-epitope protein was modeled, and af

SUBMITTER: Asadinezhad M 

PROVIDER: S-EPMC11365029 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature