Systemic coagulopathy promotes host lethality in a new Drosophila tumor model.

ABSTRACT: Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."¹ Some of these responses lead to profound defects in blood clotting, such as disseminated intravascular coagulopathy (DIC), which correlate with poor prognoses.^2,3,4 Here, we demonstrate that a new tumor model in Drosophila provokes phenotypes that resemble coagulopathies observed in patients. Fly ovarian tumors overproduce multiple secreted components of the clotting cascade and trigger hypercoagulation of fly blood (hemolymph). Hypercoagulation occurs shortly after tumor induction and is transient; it is followed by a hypocoagulative state that is defective in wou

SUBMITTER: Hsi TC 

PROVIDER: S-EPMC11365082 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature