Hi-C-guided many-polymer model to decipher 3D genome organization.

ABSTRACT: We propose a high-throughput chromosome conformation capture data-based many-polymer model that allows us to generate an ensemble of multi-scale genome structures. We demonstrate the efficacy of our model by validating the generated structures against experimental measurements and employ them to address key questions regarding genome organization. Our model first confirms a significant correlation between chromosome size and nuclear positioning. Specifically, smaller chromosomes are distributed at the core region, whereas larger chromosomes are at the periphery, interacting with the nuclear envelope. The spatial distribution of A- and B-type compartments, which is nontrivial to infer from the corresponding high-throughput chromosome conformation capture maps alone, can also be elucidated u

SUBMITTER: Shi C 

PROVIDER: S-EPMC11365109 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature