Influence of selection on the probability of fixation at a locus with multiple alleles.

ABSTRACT:

Background

Genes exist in a population in a variety of forms (alleles), as a consequence of multiple mutation events that have arisen over the course of time. In this work we consider a locus that is subject to either multiplicative or additive selection, and has n alleles, where n can take the values 2, 3, 4, … . We focus on determining the probability of fixation of each of the n alleles. For n=2 alleles, analytical results, that are 'exact', under the diffusion approximation, can be found for the fixation probability. However generally there are no equally exact results for n≥3 alleles. In the absence of such exact results, we proceed by finding results for the fixation probability, under the diffusion approximation, as a power series in scaled strengths of selection such as Ri,

SUBMITTER: Overall ADJ 

PROVIDER: S-EPMC11365252 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature