Breaking the chain in organ failure: Role of umbilical cord and bone marrow derived mesenchymal stem cells in treatment of severe acute pancreatitis.

ABSTRACT:

Background

Previous studies showed that MSCs could mitigate damage in the pancreas during acute pancreatitis (AP). However, acute mortality associated with AP was more often a result of persistent failure of remote organs, rather than local damage, especially in severe acute pancreatitis (SAP), and the effect of MSCs may vary depending on their origin.

Methods

An SAP model was induced in 8-week C57BL/6 J male mice by retrograde injection of 5 % sodium taurocholate solution through the bile duct. SAP mice were divided into the SAP group, UC-MSCs group, and BMSCs group, which were treated with saline, 1 × 10⁶ UC-MSCs, and 1 × 10⁶ BMSCs respectively, through the tail vein. After treatment, serum markers, inflammation, and morphology were assessed in the pa

SUBMITTER: Ren R 

PROVIDER: S-EPMC11365331 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature