Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes.

ABSTRACT: Obesity is primarily caused by excessive intake as well as absorption of sugar and lipid. Postprandial surge in distention pressure and intestinal motility accelerates the absorption of nutrients. The response of intestinal epithelial cells to mechanical stimulation is not fully understood. Piezo1, a mechanosensitive ion channel, is widely expressed throughout the digestive tract. However, its function in intestinal nutrient absorption is not yet clear. In our study, excessive lipid deposition was observed in the duodenum of obese patients, while duodenal Piezo1-CaMKK2-AMPKα was decreased when compared to normal-weight individuals. Under high-fat diet condition, the Piezo1 ^iKO mice exhibited abnormally elevated sugar and lipid absorption as well as severe li

SUBMITTER: Tao T 

PROVIDER: S-EPMC11365390 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature