Metabolomics-based profiling of anti-inflammatory compounds from Mentha spicata in shanghe, China.

ABSTRACT: Mentha spicata is a popular herb used in foods, cosmetics, and medicines. In the present study, liquid chromatography-mass spectrometry-based metabolomics analysis and the zebrafish model were used to investigate the potential biomarkers of M. spicata growing in Shanghe County (Shandong Province, China) and their anti-inflammatory properties. Network pharmacology and molecular docking were performed to screen the main targets of the characteristic compounds to understand their mechanisms of action. Nine potential markers including sugars (1,2), polyphenolic acids (3-5), and flavonoids (6-9) were identified from the species. The inhibitory effects on leukocyte migration confirmed that compounds 1 and 3-9 played a p

SUBMITTER: Li W 

PROVIDER: S-EPMC11365440 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature