Quantitative trait locus mapping in placenta: A comparative study of chorionic villus and birth placenta.

ABSTRACT: The placenta, a pivotal player in the prenatal environment, holds crucial insights into early developmental pathways and future health outcomes. In this study, we explored genetic molecular regulation in chorionic villus samples (CVS) from the first trimester and placenta tissue at birth. We assessed quantitative trait locus (QTL) mapping on DNA methylation and gene expression data in a Finnish cohort of 574 individuals. We found more QTLs in birth placenta than in first-trimester placenta. Nevertheless, a substantial amount of associations overlapped in their effects and showed consistent direction in both tissues, with increasing molecular genetic effects from early pregnancy to birth placenta. The identified QTLs in birth placenta were most enriched in genes with placenta-specific expre

SUBMITTER: Dieckmann L 

PROVIDER: S-EPMC11365441 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature