Impact of growth hormone-secreting pituitary adenoma on limbic system and its correlation with cognitive impairment.

ABSTRACT:

Purpose

To assess the quantitative gray matter volume of the limbic system in growth hormone-secreting pituitary adenoma (GHPAs) patients and its correlation to cognitive function.

Method

91 right-handed patients with pituitary adenomas were retrospectively included from the First Affiliated Hospital of Sun Yat-sen University -48 with GHPAs and 43 with non-functioning pituitary adenomas (NFPAs). Participants underwent serum hormone assessment, regular sellar MRI scanning with T1WI-MPRAGE. Cognitive function was gauged using MoCA and MMSE. Brain region auto-segmentation and gray matter volume calculation were conducted on the Brainsite platform.

Results

Compared to NFPAs patients, GHPAs patients had higher gray matter volume (758,285 vs 674,610 mm³, p < 0.001). No sign

SUBMITTER: Duan C 

PROVIDER: S-EPMC11365443 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature