Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy.

ABSTRACT: Drug discovery is a sophisticated process that incorporates scientific innovations and cutting-edge technologies. Compared to traditional bioactivity-based screening methods, encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency, throughput, and resource minimization. This review systematically summarizes the development history, typology, and prospective applications of encoding and displayed technologies, including phage display, ribosomal display, mRNA display, yeast cell display, one-bead one-compound, DNA-encoded, peptide nucleic acid-encoded, and new peptide-encoded technologies, and examples of preclinical and clinical translat

SUBMITTER: Fan Y 

PROVIDER: S-EPMC11365444 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature