The role of DNA topoisomerase 1α (AtTOP1α) in regulating arabidopsis meiotic recombination and chromosome segregation.

ABSTRACT: Meiosis is a critical process in sexual reproduction, and errors during this cell division can significantly impact fertility. Successful meiosis relies on the coordinated action of numerous genes involved in DNA replication, strand breaks, and subsequent rejoining. DNA topoisomerase enzymes play a vital role by regulating DNA topology, alleviating tension during replication and transcription. To elucidate the specific function of DNA topoisomerase 1α ( AtTOP1α ) in male reproductive development of Arabidopsis thaliana, we investigated meiotic cell division in Arabidopsis flower buds. Combining cytological and biochemical techniques, we aimed to reveal the novel contribution of AtTOP1α to meiosis. Our results demonstrate that the absence of AtTOP1α leads to aberrant chromatin behavi

SUBMITTER: Elesawi IE 

PROVIDER: S-EPMC11365474 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature