Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice.

ABSTRACT: Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation, known as meta-inflammation. This state is associated with the development of metabolic disorders such as glucose intolerance and nonalcoholic fatty liver disease. Pyruvate is a glycolytic metabolite and a crucial node in various metabolic pathways. However, its role and molecular mechanism in obesity and associated complications are obscure. In this study, we reported that pyruvate substantially inhibited adipogenic differentiation in vitro and its administration significantly prevented HFD-induced weight gain, white adipose tissue inflammation, and metabolic dysregulation. To identify the target proteins of pyruvate, drug affinity responsive target stability was employed with proteomics, ce

SUBMITTER: Hasan S 

PROVIDER: S-EPMC11365557 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature