Adulthood adiposity affects cardiac structure and function in later life.

ABSTRACT:

Background and aims

Excess adiposity is associated with poorer cardiac function and adverse left ventricular (LV) remodelling. However, its importance over the adult life course on future cardiac structure and systolic and diastolic function is unknown.

Methods

A total of 1690 participants in the National Survey of Health and Development birth cohort underwent repeated adiposity [body mass index (BMI)/waist-to-hip ratio (WHR)] measurements over adulthood and investigation, including echocardiography at age 60-64 years. The relationship between LV structure [LV mass (LVM), relative wall thickness, and LV internal diameter in diastole (LVIDd)] and function (diastolic: E/e', e', and left atrial volume indexed to body surface area; systolic: ejection fraction, S', and myocardial

SUBMITTER: Al Saikhan L 

PROVIDER: S-EPMC11365607 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature