Efficacy and safety of rectal chloral hydrate for pediatric procedural sedation: A systematic review and meta-analysis.

ABSTRACT:

Background

To evaluate the efficacy and safety of rectal chloral hydrate (CH) in pediatric procedural sedation.

Methods

Seven electronic databases and 3 clinical trials registry platforms were searched, and the deadline was August 2022. Randomized controlled trials evaluating the efficacy and safety of rectal CH in pediatric procedural sedation were included by 2 reviewers. The extracted outcomes included the success rate of sedation, sedation latency, sedation duration, and adverse events. The Cochrane risk of bias tool was used to assess the risk of bias. The outcomes were analyzed using Review Manager 5.3 software.

Results

Forty-four randomized controlled trials with 8007 children were included in the meta-analysis. The success rate of sedation in the rectal CH gro

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11365616 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature