Risk factors for progression from prediabetes to diabetes among older people with HIV.

ABSTRACT:

Objective

Risk factors for progression from prediabetes mellitus (pre-DM) to diabetes mellitus (DM) among people with HIV (PWH) receiving modern antiretroviral therapy (ART) require better characterization.

Design

AIDS Clinical Trials Group (ACTG) A5322 (HAILO) was an observational cohort study of PWH ≥40 years old. Participants initiated ART through ACTG randomized clinical trials.

Methods

We used Cox proportional hazards regression models to identify risk factors for development of DM among HAILO participants with pre-DM.

Results

Among 1035 HAILO participants, 74 (7%) had pre-DM at entry and another 679 (66%) developed pre-DM during follow-up. Of 753 PWH with pre-DM, 167 (22%) developed DM. In multivariable models, the risk of developing DM was greater with h

SUBMITTER: Masters MC 

PROVIDER: S-EPMC11365760 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature