Organophosphate ester flame retardant chemicals and maternal depression during pregnancy.

ABSTRACT:

Background

Depression substantially contributes to pregnancy-related morbidity, and pregnancy is increasingly recognized as a vulnerable window for exposure effects on maternal mental health. Exposures to organophosphate esters (OPEs) are ubiquitous and may have neurotoxic effects; however, their impacts on prenatal depression remain unknown. We evaluated associations of third trimester OPE metabolites on maternal depressive symptoms during pregnancy.

Methods

This study included 422 participants in the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) cohort, a prospective pregnancy cohort of primarily low-income and Hispanic participants residing in Los Angeles, California. We measured concentrations of nine OPEs in third trimester spot urine

SUBMITTER: Hernandez-Castro I 

PROVIDER: S-EPMC11365806 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature