Childhood adversity, accelerated GrimAge, and associated health consequences.

ABSTRACT: Childhood adversity is linked to psychological, behavioral, and physical health problems, including obesity and cardiometabolic disease. Epigenetic alterations are one pathway through which the effects of early life stress and adversity might persist into adulthood. Epigenetic mechanisms have also been proposed to explain why cardiometabolic health can vary greatly between individuals with similar Body Mass Index (BMIs). We evaluated two independent cross-sectional cohorts of adults without known medical illness, one of which explicitly recruited individuals with early life stress (ELS) and control participants (n = 195), and the other a general community sample (n = 477). In these cohorts, we examine associations between childhood adversity, epigenetic aging, and metabolic health. Childho

SUBMITTER: Harvanek ZM 

PROVIDER: S-EPMC11365810 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature