Multi-epitope vaccine design of African swine fever virus considering T cell and B cell immunogenicity.

ABSTRACT: T and B cell activation are equally important in triggering and orchestrating adaptive host responses to design multi-epitope African swine fever virus (ASFV) vaccines. However, few design methods have considered the trade-off between T and B cell immunogenicity when identifying promising ASFV epitopes. This work proposed a novel Pareto front-based ASFV screening method PFAS to identify promising epitopes for designing multi-epitope vaccines utilizing five ASFV Georgia 2007/1 sequences. To accurately predict T cell immunogenicity, four scoring methods were used to estimate the T cell activation in the four stages, including proteasomal cleavage probability, transporter associated with antigen processing transport efficiency, class I binding affinity of the major histocompatibility complex,

SUBMITTER: Chen TY 

PROVIDER: S-EPMC11365882 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature