Structural and functional connectivity in relation to executive functions in antipsychotic-naive patients with first episode schizophrenia and levels of glutamatergic metabolites.

ABSTRACT: Patients with schizophrenia exhibit structural and functional dysconnectivity but the relationship to the well-documented cognitive impairments is less clear. This study investigates associations between structural and functional connectivity and executive functions in antipsychotic-naïve patients experiencing schizophrenia. Sixty-four patients with schizophrenia and 95 matched controls underwent cognitive testing, diffusion weighted imaging and resting state functional magnetic resonance imaging. In the primary analyses, groupwise interactions between structural connectivity as measured by fixel-based analyses and executive functions were investigated using multivariate linear regression analyses. For significant structural connections, secondary analyses examined whether functional conne

SUBMITTER: Kristensen TD 

PROVIDER: S-EPMC11366027 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature