Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial.

ABSTRACT:

Importance

Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used to prevent atrial fibrillation after cardiac surgery (AFACS), but is not evidence-based, carries risks, and is costly.

Objective

To determine whether a lower serum potassium concentration trigger for supplementation is noninferior to a high-normal trigger.

Design, setting, and participants

This open-label, noninferiority, randomized clinical trial was conducted at 23 cardiac surgical centers in the United Kingdom and Germany. Between October 20, 2020, and November 16, 2023, patients with no history of atrial dysrhythmias scheduled for isolated coronary artery bypass grafting (CABG) surgery were enrolled. The last study patient was discharged from

SUBMITTER: O'Brien B 

PROVIDER: S-EPMC11366075 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature